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de la Asuncion JG, Millan A, Pla R, Bruseghini L, Esteras A, et al

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Because phosphatidylcholine is required in the synthesis of very-low-density lipoprotein (VLDL) particles (see Function), choline deficiency results in impaired VLDL secretion and accumulation of fat in the liver (steatosis), ultimately leading to liver damage

Research emphasizes protective carriers, targeted transport, and non-invasive approaches to minimize enzymatic breakdown and enhance bioavailability