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Hearts from heterozygous (GPx1 +/ ) knockout mice were more susceptible to diastolic dysfunction following ischemia/reperfusion (I/R) injury than wildtype hearts [39] and GPx1 / hearts (from male mice) showed both contractile and diastolic dysfunction following I/R, with an increase in oxidative stress as measured by an increase in protein carbonylation [40]

Like allopurinol, the most common side-effect of febuxostat is causing gout to flare after this drug is started

However, its use in healthy individuals for performance enhancement can be risky and is often illegal in competitive sports

And it affects glucagon secretion to improve metabolic regulation

This difference in hormonal activity may lead to slightly different metabolic effects and weight loss responses