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However, a CGRP isnt solely responsible for migraines, and medications that target CGRP only work for a portion of patients.[ref] CGRP can also bind to the amylin 1 receptor in the brain

Similarly, chronic inflammation driven by a diet high in processed foods, refined sugars, and seed oils can counteract the anti-inflammatory effects of the peptide, essentially working against your treatment

They might respond better to a different medication. There are also questions about the safety of GLP-1 agonists in the context of significant alcohol consumption given the small risk of pancreatitis, Professor Samaras said