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2021 Oct;88(10):673-685

SCFA-producing bacteria in the gut influence the expression of tryptophan hydroxylase and thereby 5-HT synthesis and release [220], potentially affecting 5-HT levels in the brain [75, 79]

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In the SURMOUNT-1 trial [16], among the pooled tirzepatide groups, there was a 7.2 mmHg reduction in systolic blood pressure with reductions in non-HDL-C and triglycerides of 9.7% and 24.8%, respectively, and increases in HDL-C of 8.0%

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