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TNF- treatment, for instance, causes sustained downregulation of GPX4, rendering cells more susceptible to ferroptosis [166]

In a different study, hepatic FOXO1 ablation in mice was compared with the simultaneous knockout of FOXO1 and FOXO3 and the triple ablation of the three isoforms, FOXO1, FOXO3, and FOXO4 in the liver

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