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In addition, kindling may also be responsible for high levels of oxidative stress, which has been found in patients with ME/CFS. Once primed (which may reflect structural changes to the brain) very little stimulus is needed to trigger a flare of neuroinflammation

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the cause of accelerated phospholipid flip-flop leading to an enhanced procoagulant activity of sickled cells

The iron-overloaded environment of follicular fluid could not only inhibit the expression of GPX4 and its upstream regulatory target GSH but also cause the high expression of NCOA4 in granulosa cells

Clinical trials have demonstrated its efficacy and safety, particularly when co-administered with semaglutide