The insulin-like growth factor system in chronic kidney disease: Pathophysiology and therapeutic opportunities
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In DKD, hyperglycemia induces the overexpression of chemokines and cytokines in damaged glomeruli and renal tubules, which aggravate renal injury through a variety of mechanisms, such as leukocyte infiltration, renal filtration barrier breakdown and mesangial proliferation[97, 98]
5 Drawbacks of current treatment methods The enteral route of administration has some shortcomings for oral administration, though
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The last option maintains therapeutic continuity when the commercial product is temporarily inaccessible