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Zannad F, Cannon CP, Cushman WC, Bakris GL, Menon V, Perez AT, et al

M., Vzquez-Carrada, M., Uribe-Ramrez, D., & Matuz-Mares, D

Examples include: Sulfasalazine (brand name: Azulfidine) Mesalamine (brand names: Asacol, Pentasa, Apriso, Lialda, Delzicol) Balsalazide (brand names: Giazo, Colazal) Olsalazine (brand name: Dipentum) Sulfasalazine, balsalazide and olsalazine are oral medications that work in different ways to lessen inflammation in the large intestine (colon and rectum)

Works well for many patients, especially those new to GLP-1 therapy

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Trials typically incorporate biomarker endpoints such as ER/ER ratios, aromatase activity, plasma isoflavone or polyphenol concentrations, immune cell phenotyping, cytokine panels, oxidative stress markers and microbiome profile which are used to provide mechanistic read-outs of supplement activity and to inform patient stratification approaches (231)