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As atherosclerotic plaques develop and advance, coronary blood flow becomes increasingly restricted, particularly during periods of elevated myocardial oxygen demand such as physical exertion or emotional stress

EsfandiariAPourghassem GargariBNoshadHSarbakhshPMobasseriMBarzegariMet al

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The lack of cat2 up-regulation in yap1 is consistent with the function of Yap1 as an activator of oxidative stress response 28

Cui P, Tang Z, Zhan Q, Deng C, Lai Y, Zhu F, et al

In accordance with such a variety of functions, isoforms of this heterogeneous protein family are found in many prokaryotes as well as in the cytosol, nucleus, mitochondria, chloroplasts and/or secretory pathway of eukaryotes 1,2,3,4,5,6,7,8