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10.1046/j.1460-9568.2000.00126.x 141

The rest is history

However, many of these technologies remain preclinical or are early in development, and larger-scale, longer-term studies are required to more conclusively assess their long-term effectiveness, safety, and cost-efficiency before routine clinical use

Disruption of this gene can lead to diseases such as neurodegenerative disorders, cardiovascular issues, and cancer