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SEP-479 oral small-molecule agonist of the parathyroid hormone 1 receptor (PTH1R) aimed at treating hypoparathyroidism Recent Highlights: In May 2025, Septerna signed an exclusive global collaboration with Novo Nordisk worth up to $2.2B to co-develop oral small molecule GLP-1, GIP, and glucagon receptor agonists

Proc Natl Acad Sci 106(34):1472814733 Hashim H, Azmin S, Razlan H, Yahya NW, Tan HJ, Manaf MR, Ibrahim NM (2014) Eradication of Helicobacter pylori infection improves levodopa action, clinical symptoms and quality of life in patients with Parkinsons disease

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PPAR is a nuclear receptor involved in fat oxidation, energy expenditure, and mitochondrial function

It is a synthetic compound composed of 15 amino acids derived from a protein called body protection compound found in human gastric juice

Users in community sources commonly describe it as similar to starting an anti-inflammatory protocol, fading by week 2