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A Chinese RCT including 37 normal BMI, 37 overweight, and 26 obese T2D patients found that the hypoglycemic efficacy of liraglutide was positively correlated with BMI, being most effective in patients with obesity 40

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Vitamin B12 also modulates gut microbiota, such as increasing the Firmicutes-to-Bacteroidetes ratio, elevating the relative abundance of Faecalibacterium , decreasing Bacteroides populations, and promoting the production of SCFAs, particularly butyrate (77)