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Guanylate Cyclase-C Agonists Examples: Linaclotide, Plecanatide Mechanism: cGMP activates CFTR channels intestinal fluid secretion accelerate transit Uses: Chronic constipation, IBS-C Adverse Effects: Diarrhea, abdominal pain Bulk-forming safest, long-term use Osmotic acute or hepatic encephalopathy (lactulose) Stimulants short-term only Stool softeners post-surgery, hemorrhoids Lubricants avoid long-term Chloride channel activators & GC-C agonists newer agents for chronic constipation Mnemonic for Laxatives: BOSS-LC B Bulk-forming O Osmotic S Stimulant S Stool softeners L Lubricant C Chloride channel activators / cGMP agonists To view or add a comment, sign in Sodium bicarbonate (NaHCO) is a systemic alkalinizing agent used to correct metabolic acidosis and as a source of bicarbonate ions in various clinical situations
Weight Loss Injections Including Semaglutide, Tirzepatide, peptides, and alternatives to popular medications like Ozempic and Mounjaro
If you have obesity, significant problems with appetite regulation and losing weight, or type 2 diabetes, Ozempic could be a better option
Some researchers suggest that it should only be administered on supplementary tanning session days, and that the melanotan II injection should precede supplementary tanning sessions by about one hour at most
Women of childbearing potential should use effective contraception while taking Wegovy