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It is worth noting that in yeast SF3B1 lacks an IDR, and CDK11 is absent 20 , however a SNIP1 yeast homolog, Pml1p, contains an FHA domain 117

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This dual function may explain its superior performance compared to single-function peptides

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In SURPASS-2 (N=1,879), tirzepatide 15 mg produced a 2.58% HbA1c reduction versus 1.86% for semaglutide 1 mg at 40 weeks, with 5.5 kg greater weight loss [7]