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eNOS uncoupling Under certain conditions, eNOS can become uncoupled, shifting from producing NO to generating superoxide (O 2 ), which not only reduces NO availability but also increases oxidative stress, reducing endothelial dysfunction

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Therefore, future research should focus on deepening our understanding of ferroptosis mechanisms in CAD and developing more effective and safer clinical intervention strategies to enhance CHD management

Munzel et al., 1995b