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Patients with T2DM with documented or at risk for cardiovascular events were randomly assigned to receive saxagliptin or placebo

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suggest that GLP-1 improves endothelial dysfunction during hyperglycemia and may reduce oxaidative stress generation ( n = 12) compared to type 2 diabetes mellitus patients ( n = 16) had lower levels of glycemia, flow-mediated vasodilation (FMD), plasma nitrotyrosine and plasma 8-iso prostaglandin F2 (8-iso-PGF2a) after standar meal and oral glucose tolerance test (OGTT) and after two months of insulin treatment

Reduction of daily physical and mental fatigue