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[12] The active site of GGT is known to be located in the light subunit

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Another Nrf2-regulated protein is the stress responsive inducible enzyme heme oxygenase 1 (HO-1), which metabolizes prooxidant heme to the antioxidant pigment biliverdin, ferrous iron and carbon monoxide 8

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Nrf 2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress