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( b ) Fcr3b but not other FcRs expression is negatively associated with GPX4 reduction

When dysregulated iron metabolism, impaired antioxidant defenses (such as GPX4 inactivation or system Xc inhibition), and excessive lipid peroxidation converge, ferroptosis contributes directly to cardiovascular disease pathogenesis

Journal of Water Process Engineering, 58 , 104850

Excess ROS then activates the NLRP3 inflammasome in microglia, promoting maturation and release of IL-1 ( 4.3 GSH metabolism: a central hub in mid-late SAE The hippocampus, with its high metabolic demands and low antioxidant capacity, is uniquely vulnerable to septic injury ( A Stat1-Gpx3 hub was identified, where TNF-/IL-1-induced Stat1 activation suppresses Nrf2 (confirmed by reduced hippocampal Nrf2)

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