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Notably, the in vivo pharmacokinetic evaluations in a Sprague Dawley rat model revealed a 16.8-fold increase in plasma half-life and a 16.1-fold improvement in oral bioavailability compared to native GSH

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I generally recommend starting with the lower dose of 0.25 mg for the first week before considering increases

Long-Term Side Effects Many side effects associated with the long-term use of Wellbutrin are similar to those explained above

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Restarting at a lower dose can help confirm a pattern, but if a new or severe headache appears, stop and consult a clinician