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Limitations : Risk of hypothyroidism requiring lifelong hormone replacement, delayed therapeutic effects, and potential worsening of ophthalmopathy

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These results suggested the possibility of GLP-1 as a treatment for diabetes, but limitations for therapeutic utility existed as endogenous GLP-1 had a short half-life in plasma of 1 to 2 minutes, degraded by the dipeptidyl-peptidase 4 (DPP-4) enzyme [13]