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This result is notable when compared to other medications in the same timeframe: - Cagrilintide (Novo Nordisk): 5.0% weight loss - Semaglutide (Novo Nordisk): 5.3% weight loss - Tirzepatide (Eli Lilly): 8.2% weight loss Despite the smaller sample size (N=12) and the early phase of clinical development, Petrelintide shows significant potential

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GLP-1 anorexia beyond the direct hypothalamus/hindbrain action Central or peripheral GLP-1 injection reduces food intake in rodents and man (Turton et al., 1996