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For myocardial infarction, GLP-1RAs alleviate and repair MI via SIRT1/Parkin/mitophagy, insulin-like growth factor-1/2 and upregulating -estrogen receptor
G protein-coupled receptor 40 (GPR40) The orthosteric partial GPR40 agonist TAK-875 (fasiglifam) resulted in glucose improvement in T2D patients (131) but the development was halted in Phase III due to potential liver toxicity (132)
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