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This mechanism could be due to blockade of the NF-B pathway, activation of nuclear factor-erythroid 2-related factor-2 (NRF2) signaling, and enhanced mitochondrial repair within activated microglia, which results in the suppression of the TNF- positive feedback loop and CCL3 and CCL6 signaling [225, 226]

Along with immunosuppressive strategies [2], synthetic lipophilic radical traps that cross the blood-brain barrier could be considered as novel treatment options controlling oligodendrocyte and neuronal cell death

Blood 140 , 20372052 (2022)

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Antineoplastic efficacy of melphalan and N-(2-chloroethyl)-N-nitrosocarbamoyl--lysine, in combination with diazoxide or insulin in autochthonous mammary carcinoma of the Sprague-Dawley rat