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The goal is to let the hypothalamic-pituitary axis adjust gradually

Based on evidence from clinical studies, the USPHS, AAP, and ACOG recommend a folic acid intake of 0.4 mg/day PO from food and/or supplements in females during the child-bearing years, and 0.6 mg PO daily throughout pregnancy

observed a decrease in B12 and folate levels and an increase in homocysteine levels in relapsingremitting MS patients [124]