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The absoption of CoQ 10 is slow and limited due to its hydrophobicity and large molecular weight and, therefore, high doses are needed to reach a number of rat tissues (e.g., muscle and brain) (Bhagavan and Chopra, 2006) and we can only assume that this also happens in humans

doi:10.1186/1741-7015-9-71 Nicoletti CF, Suen VM, de Oliveira M, Nonino CB

doi: 10.4103/1673-5374.194803 75 HerS.LeeM.-S.MoritaK

Some practitioners suggest taking liposomal glutathione on an empty stomach for maximum absorption, as food can compete with lipid absorption pathways

Its usually recommended to use the drops on an empty mouth for optimal absorption

van der Windt, D