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Alpha BRAIN has been the subject of two clinical studies, neither of which looked at the safety of long-term regular use
The high neutrophil to lymphocyte ratio in critically ill patients, the intense neutrophil infiltration in pulmonary capillaries and into pulmonary alveoli, and the increased levels of circulating neutrophil extracellular traps (NETs) clearly show neutrophil involvement/activation favoring intense ROS production and oxidative damage caused by lipid peroxidation, and protein and DNA oxidation (Komaravelli and Casola, 2014
doi: 10.1093/humupd/dmab026 166
Notably, activation of such pro-inflammatory mechanisms can directly cause excess generation of oxidation products that precede the onset of atherosclerosis and endothelial dysfunction, which are major risk factors for the development of cardiovascular diseases (Rose et al., 2010
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