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DOI: 10.1016/j.biocel.2006.07.001 21

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This pathogenic cascade is central to celiac disease, where gluten is an established environmental trigger rather than a hypothetical contributor ( HT is the most common autoimmune cause of hypothyroidism and results from loss of immune tolerance to thyroid antigens, particularly thyroid peroxidase and thyroglobulin

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27 The major limitations of this study are the lack of verifiable diagnoses reported by respondents, lack of objective symptom improvement, and low survey response rate, all of which were anticipated weaknesses given the study design