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In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose, and lipids. Data from the first and largest of Lillys pivotal trials showed participants taking Tirzepatide lost as much as 25 pounds on average over 40 weeks (with additional lifestyle modifications)

Ipamorelin's highly specific receptor binding profile avoids these hormonal side effects at therapeutic doses, which is why it replaced GHRP-6 as the preferred ghrelin-receptor agonist in clinical practice