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In summary, impaired prefrontal cortical function in elevated mood states may result in compromised regulation of limbic and paralimbic areas, manifesting as excessive emotional reactivity, irritability, impulsivity, difficulty conforming emotional responses to the social milieu, excessive indulgence of appetitive drives, and cognitive/attentional impairment

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PMID: 11101503)

It does so without affecting other hormones like cortisol, prolactin, and aldosterone

The experience of tiredness can vary considerably between individualssome may notice mild lethargy during the initial weeks of treatment, whilst others may experience more persistent symptoms that affect daily functioning

Although melanotan 2 researchers have primarily favored injections, a nasal spray format may facilitate research if injections are not possible or suboptimal in certain research settings