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CBS cystathionine-beta-synthetase the methionine remethylation step can be facilitated by several intermediates such as the well known reaction mediated by folic acid and its active metabolites to form 5-methyltetrahydrofolate (5-MTHF) creating tetrahydrofolate (THF) which will then regenerate to 5-MTHF through the action of methylenetetrahydrofolate reductase (MTHFR)

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doi: 10.1067/mlc.2000.105977

Finally, integrating diagnostic and therapeutic functions within redox-responsive theranostics using activatable probes or dual-mode imaging may enable real-time monitoring and precision dosing in clinical settings