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In vitro GSH sensitivity and selectivity experiments The HT adducts were prepared by combining the HT protein (~50 M in PBS) with the respective TRaQ-G ligand (1.52 excess, stock solution 50 mM in DMSO) and rotating the resulting solution for 1 h at 20 C

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The availability of isoform-specific binding partners or small molecules could enable targeted protein degradation using proteolysis targeting chimaeras (PROTACs)