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Notably, the effects observed with hypoxia treatment were replicated using Akt and ERK1/2 MAPK inhibitors (20), indicating that hypoxia-induced tissue damage may involve multiple pathways

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Dedicated constitutional (germline) testing using a DNA and RNA-based platform (Invitae Multi-Cancer+RNA Panel) was performed on whole blood and was negative for all alterations, including in PRKAR1A

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