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Such bidirectional interaction between hyperandrogenism and insulin resistance/hyperinsulinemia likely plays a key role in the pathogenesis of PCOS 12,13,14 , since elevated testosterone promotes obesity and insulin resistance/hyperinsulinemia by altering body composition and insulin signaling in skeletal muscle and adipose tissue, while hyperinsulinemia contributes to increase androgen levels via ovarian-dependent mechanisms 5

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Retrieved October 11, 2024

There are hormonal changes, muscle loss, sleep issues many things converging at once. In December 2025, the World Health Organization (WHO) issued global guidance on the use of GLP-1 for treating obesity

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According to the Wegovy SmPC, treatment should be reviewed after 6 months at the maintenance dose (2.4 mg or maximum tolerated dose)