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FOXO4 knockdown resulted in increased levels of p53 and Ser15-phospho-p53, but paradoxically decreased the level of p21

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Therefore, in this review, we summarize and briefly present the key pathways of ferroptosis, paying special attention to the regulation of ferroptosis as well as its dual role as an oncogenic and as a tumor suppressor event in various human cancers

the tissue was circled with a histochemical pen, incubated with autofluorescence quenching agent (G1221, ServiceBio, Wuhan, China) for 5 min, and then rinsed

& Tacnet, F

The activation of the Nrf2 pathway triggers a massive endogenous production of Phase II detoxification enzymes, including Heme Oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1)