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This displaced material may press against nearby nerve roots, causing the characteristic pain, numbness, and weakness associated with disc problems

C-terminal fusions of Hoc were inefficient (Figure 3 A and B)

3ac) showed minimal toxicities, even at high concentrations (100 M or more)

The uricosuric agents targeting the URAT1 transporter, such as lesinurad and dotinurad, along with the formulation of oral combination therapies comprising xanthine oxidase inhibitors and uricosuric agents, is poised to improve the attainment of the target serum uric acid level of less than 6 mg/dL

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