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Researchers once reported metabolically healthy but obese individuals had two- to three-fold higher expressions of genes associated with adipocyte differentiation, though the proportion of small adipocytes was actually lower than metabolically abnormal obese individuals, which may share some similarities with PWS patients [36]

Ann Neurol 38:35766, PMID: 7668820 Ogita K, Shuto M, Maeda H, Minami T, Yoneda Y (1998) Possible modulation by glutathione of glutamatergic neurotransmission

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Once food-related cues acquire negative predictive value, they may trigger avoidance responses and lead to an earlier decline in motivational drive (wanting) (91)

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Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability