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Additional symptoms may occur during an episode including paleness of the skin (pallor), lack of energy (lethargy), fever and drooling

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In a streptozotocin-induced diabetic rat model, treatment with methanolic leaf extract led to a marked decrease in hepatic and renal levels of IL-1, IL-12, IL-18, and NF-B, while also exhibiting antioxidant and anti-apoptotic effects [77]

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Meta-analyses show reductions in body weight and fat mass in overweight individuals when combined with diet/exercise

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