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This rapid clearance might suggest the need for larger doses, yet the peptide initiates cellular processes that continue long after the compound itself has been metabolized

ET: This article was updated with a statement from a Lilly spokesperson

Semaglutide does not alter thyroid hormone levels or TSH in clinical studies, so thyroid medication typically remains unchanged

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By improving insulin sensitivity and supporting better blood sugar control, tirzepatide not only helps reduce the risk of overeating but also promotes gradual, sustainable weight loss