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Another study identified potential inhibitors through in silico screening, discovering several chemotypes that inhibited NAPRT at micromolar concentrations

Surplus ROS attack DNA, inducing damage [107], and oxidize proteins, leading to protein misfolding and functional loss [108]

This suppressed the activation of transposable elements and prevented genomic instability (Bollati et al., 2011)

Inhibition of ASK1 activity significantly inhibits the development of NASH

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