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doi: 10.4161/cbt.9.1.10392

A randomized, open, controlled trial comparing tretinoin 0.05% cream with low-dose oral isotretinoin was conducted for the purpose of treating field cancerization

Like the other B vitamins, vitamin B12 cannot be synthesized in the body and must be obtained through food sources or supplementation

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Instead, it appears to work indirectly by stimulating release of met-enkephalin, one of the body's natural opioid peptides

This finding provides high-level clinical evidence supporting the use of traditional Chinese medicineeither alone or in combination with Western medicinefor PCOS treatment, further highlighting its therapeutic potential and unique value in the comprehensive management of this condition