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doi: 10.3389/fpsyt.2020.00351 183 YuanM.LiuB.YangB.DangW.XieH.LuiS.et al

Stamp for 5 to 10 minutes across seven facial zones (forehead, both cheeks, nose bridge, both lower jaw segments, chin) using a 50 percent overlap technique

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As a pharmacological agent, papaverine is not exempt from adverse effects including endothelium damage, epileptic seizures, transient neurological dysfunction, and hemodynamic changes, among others (Dipp et al., 2001