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The first time was when the study initially appeared

10.3390/medicina55090602 Medicina 31 CameronH

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This gut-derived inflammation fuels liver injury by triggering immune responses and enhancing HSC activation.12 Similarly, the adipose-liver axis involves the release of adipokines and free fatty acids from adipose tissue, which aggravate hepatic steatosis and inflammation, further contributing to ALD progression.13 Given the rising prevalence and complexity of ALD, it is critical to synthesise existing knowledge and identify gaps in our understanding of its pathogenesis

These applications fall outside general consumer guidelines and should follow professional recommendations