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Moreover, the observations that ferroptosis and monocyte infiltration were progressively increased with increasing durations of infection confirm that HSV-1-induced ferroptosis is tightly associated with the process of viral encephalitis

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383,384 Once IL-6 binds to IL-6R, the IL-6/IL-6R complex is able to activate its coreceptor gp130, which initiates downstream pathways, including the JAK/STAT3, PI3K/AKT, and MAPK pathways