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This combination promotes the increase of GH by both increasing the strength of the GH release pulse and increasing the number of cells that secrete GH with the two pathways converging on the somatotroph to produce a supraphysiological GH response that neither compound achieves independently

Figure 6 3.7

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DNA methylation at CpG sites across the genome changes in systematic, age-predictive patterns that are measurable as "epigenetic age" with biological epigenetic age sometimes running ahead of or behind chronological age based on genetics, lifestyle, and metabolic health