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It is actually one of the symptoms of pernicious anemia that people may notice first and is a symptom that may respond quickly to B12 supplementation
DNA Repair When DNA is exposed to ROS, it induces an oxidative base modification that could result in transcriptional mutagenesis (Lindahl, 1993), two processes that leads to genomic instability and cell death (Rodier et al., 2009)
However, the exact way NNMT works still needs more exploration, and further studies are needed to fully understand and develop treatments focused on NNMT
Regulatory and safety status: It's pending FDA review and not currently approved for use in humans
(PubMed) Kanai F, Marignani PA, Sarbassova D, et al