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The peptides mechanism relies on beta-3 adrenergic receptor modulation and potentially other adipocyte-specific pathways

Humans cannot synthesize PABA nor attach glutamate residues to pteroic acid, thus, requiring folic acid or folate (DHF or THF) intake in the diet

2) it augments neuronal connectivity, a necessary property when faced with loss of neuronal connectivity

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Salehi B, Berkay Ylmaz Y, Antika G, Boyunegmez Tumer T, Fawzi Mahomoodally M, Lobine D, Akram M, Riaz M, Capanoglu E, Sharopov F, Martins N, Cho WC, Sharifi-Rad J. Insights on the Use of -Lipoic Acid for Therapeutic Purposes. Biomolecules. 2019 Aug 9;9(8):356. doi: 10.3390/biom9080356. PMID: 31405030; PMCID: PMC6723188

doi: 10.1158/1541-7786.MCR-05-0261 84 SotoAMSonnenscheinC