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High-dose oral B12 supplements are available over the counter for a few dollars per month, while injection visits typically involve copays, administration fees, and the time cost of repeated clinic appointments

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The same pattern likely applies to both CagriSema and tirzepatide, though long-term discontinuation data for both is limited

Selected Preclinical Data Study 1: Genetic Proof-of-Concept A seminal investigation reported elevated NNMT expression in white adipose tissue (WAT) and liver of obese/diabetic mice