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Botanicals in cancer trials

Historically, PAs were implicated in the etiology of schizophrenia because certain antipsychotic and antimalarial drugs contain structural components resembling spermidine and were associated with extrapyramidal symptoms and psychosis (84)

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Investigators have described this pattern as a "broad reset" of pathways associated with cellular aging language that, while evocative, remains pre-clinical and has not been translated into validated human therapeutic claims