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Side effects with current GLP-1 drugs are attributed to the triggering of alternative pathways

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Longevity pathways activated NAD+-dependent enzymes like SIRT1, tied to DNA repair and stress response, become more active

Oral bioavailability and BBB permeability: CSF1Ri compounds exhibit good oral activity and brain penetration, enabling long-term and reversible microglial depletion, which facilitates in-depth studies of microglial roles in neurodevelopment, homeostasis, and disease

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