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MMs with KIT mutations presumably affect the function of juxta-membrane autoinhibitory domain (JMD) (W557R, N566D, V559A, V559D, V560D, V569G, P573L, L576P, K642E) and tyrosine kinase domains (D816H, D820Y, A829P, N822K), causing constitutive activation of C-KIT-regulated pathways (8184)

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Other, weaker risk factors: Renal dysfunction